Retatrutide (RETA) is a next-generation investigational triple hormone receptor agonist designed to activate GLP-1, GIP, and glucagon receptors simultaneously. This unique mechanism has made it one of the most promising metabolic peptides currently under investigation, with Phase 3 clinical trials demonstrating unprecedented results across weight management and multiple obesity-related conditions.
Unlike traditional GLP-1 therapies, Retatrutide's triple-agonist approach is being studied for its ability to not only reduce appetite, but also increase energy expenditure, improve metabolic health, and address several obesity-related complications. Recent Phase 3 TRIUMPH studies have shown average weight reductions of up to 28.3% over 80 weeks, with nearly half of participants achieving at least 30% body weight reduction.
Beyond weight management, Retatrutide continues to demonstrate encouraging results in multiple areas of metabolic research. Recent studies have reported improvements in:
- Significant reductions in visceral body fat
- Blood glucose and HbA1c control
- Blood pressure
- Triglycerides and non-HDL cholesterol
- Inflammatory markers (including hs-CRP)
- Waist circumference
- Obstructive sleep apnea severity
- Knee osteoarthritis pain and physical function
- Overall cardiometabolic health and metabolic efficiency
Retatrutide is also being actively investigated in ongoing clinical trials for additional obesity-related conditions, including cardiovascular disease, metabolic dysfunction-associated steatotic liver disease (MASH), type 2 diabetes, sleep apnea, and long-term cardiometabolic outcomes.
Areas of Ongoing Research
- Body weight management
- Appetite regulation
- Energy expenditure
- Fat metabolism
- Visceral fat reduction
- Blood glucose and insulin sensitivity
- Cardiovascular risk factors
- Sleep apnea
- Knee osteoarthritis
- Liver health (MASH)
- Metabolic health and longevity
Product Information
- Peptide: Retatrutide (RETA)
- Strength: 10 mg per vial
- Purity: High-purity research-grade peptide
- Appearance: Lyophilized (freeze-dried) powder
- Storage: Store refrigerated. For long-term storage, unopened vials may be kept frozen.
For laboratory and research use only. Not intended for human consumption, diagnosis, treatment, or prevention of any disease.
Additional information
| Weight | 0.454 lbs |
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